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Q: I recently had a lumpectomy to treat ductal carcinoma in situ. I am now considering post-surgical radiation treatment. How effective is post surgical radiation for this? Is it necessary for me to undergo radiation?
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Dr. Garnick is an internationally renowned expert in medical oncology and urologic cancer, with a special emphasis on prostate cancer. He is a Clinical Professor of Medicine at Harvard Medical School and maintains an active oncology practice at Beth Israel Deaconess Medical Center. Dr. Garnick serves as Editor in Chief of Perspectives on Prostate Diseases, an annual report from Harvard Health Publications.

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February 11, 2010
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A:

Ductal carcinoma in situ (DCIS) is a very common form of breast cancer.

It is limited to the ductal system within the breast. This means it has not yet invaded the tissue substance of the breast.

In the past, DCIS has generally been treated by removing the abnormal tissue and examining the "margins" of where the cancer was located to look for stray abnormal cells.

Whether to add radiation afterwards is difficult to say.

On one hand, studies have shown a decrease in the likelihood that a tumor will return or turn into invasive cancer in those who received radiation compared to those who did not.

On the other hand, more recent views have questioned whether routine radiation is needed. This is especially true if the surgical removal has been meticulous and a pathological study performed. Also, many studies in favor of radiation were done before we had detailed mammographic evaluations after the surgery.

So, the answer to your question about radiation depends upon several factors:

  • Your individual risk factor for breast cancer
  • The amount of experience and level of expertise of the surgeon, pathologist and radiologist in removing, evaluating and imaging breast tissue
  • How often your doctors see patients with DCIS and their level of comfort with one recommendation vs another

Many patients with DCIS are accessed for their risk of having a tumor return. For example, the Van Nuys system looks at the pathologic appearance, margins around the DCIS, and other factors. In patients with low risk, radiation treatments may not always be recommended.

If you are being treated in a hospital that has access to all the recent recommendations, I would defer to your doctors' recommendation. However, if your hospital does not work with many DCIS patients, it may make more sense to get the post-operative radiation.

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